Obesity Contributes to Ovarian Cancer Metastatic Success Through Increased Lipogenesis, Enhanced Vascularity, and Decreased Infiltration of M1 Macrophages

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancy, with high mortality attributable to widespread intra-peritoneal (i.p.) metastases. Recent meta-analyses report an association between obesity, ovarian cancer incidence, and ovarian cancer survival, but the eff...

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Udgivet i:Cancer Res
Main Authors: Liu, Yueying, Metzinger, Matthew N., Lewellen, Kyle A., Cripps, Stephanie N., Carey, Kyle D., Harper, Elizabeth I., Shi, Zonggao, Tarwater, Laura, Grisoli, Annie, Lee, Eric, Slusarz, Ania, Yang, Jing, Loughran, Elizabeth A., Conley, Kaitlyn, Johnson, Jeff J., Klymenko, Yuliya, Bruney, Lana, Liang, Zhong, Dovichi, Norman J., Cheatham, Bentley, Leevy, W. Matthew, Stack, M. Sharon
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668203/
https://ncbi.nlm.nih.gov/pubmed/26573796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0706
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