Lysophosphatidic acid modulates ovarian cancer multicellular aggregate assembly and metastatic dissemination

Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into the peritoneal cavity, adhesion to and retraction of peritoneal mesothelial cells and subsequent anchoring. Elevated levels of lysophosphatidic acid (LPA) have been linke...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Klymenko, Yuliya, Bos, Brandi, Campbell, Leigh, Loughran, Elizabeth, Liu, Yueying, Yang, Jing, Kim, Oleg, Stack, M. Sharon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331713/
https://ncbi.nlm.nih.gov/pubmed/32616784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67565-7
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