Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

The nitric oxide synthase inhibitor NG-nitro-L-arginine (NO2Arg) blocks morphine tolerance in mice. After implantation of morphine pellets the analgesic response decreases from 100% on the first day to 0% on the third. Coadministration of NO2Arg along with the pellets markedly retards the developmen...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Kolesnikov, Y A, Pick, C G, Ciszewska, G, Pasternak, G W
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1993
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC46675/
https://ncbi.nlm.nih.gov/pubmed/7685116
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