Mycobacterium tuberculosis Infection Induces HDAC1-Mediated Suppression of IL-12B Gene Expression in Macrophages

Downregulation of host gene expression is one of the many strategies employed by intracellular pathogens such as Mycobacterium tuberculosis (MTB) to survive inside the macrophages and cause disease. The underlying molecular mechanism behind the downregulation of host defense gene expression is large...

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Veröffentlicht in:Front Cell Infect Microbiol
Hauptverfasser: Chandran, Aneesh, Antony, Cecil, Jose, Leny, Mundayoor, Sathish, Natarajan, Krishnamurthy, Kumar, R. Ajay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667035/
https://ncbi.nlm.nih.gov/pubmed/26697414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2015.00090
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