The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome

Ang II type 1a receptor (AT(1a)R)-mediated activation of MAPKs contributes to thoracic aortic aneurysm (TAA) development in Marfan syndrome (MFS). β-Arrestin2 (βarr2) is known to mediate AT(1a)R-dependent MAPK activation, as well as proproliferative and profibrotic signaling in aortic vascular smoot...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Wisler, James W., Harris, Emily M., Raisch, Michael, Mao, Lan, Kim, Jihee, Rockman, Howard A., Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666970/
https://ncbi.nlm.nih.gov/pubmed/26371162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00291.2015
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