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The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome
Ang II type 1a receptor (AT(1a)R)-mediated activation of MAPKs contributes to thoracic aortic aneurysm (TAA) development in Marfan syndrome (MFS). β-Arrestin2 (βarr2) is known to mediate AT(1a)R-dependent MAPK activation, as well as proproliferative and profibrotic signaling in aortic vascular smoot...
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| 出版年: | Am J Physiol Heart Circ Physiol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4666970/ https://ncbi.nlm.nih.gov/pubmed/26371162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00291.2015 |
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