Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics

The objective of this study was to establish whether alterations in the REDD1-mTOR axis underlie skeletal muscle insensitivity to insulin in Type 2 diabetic (T2D), obese individuals. Vastus lateralis muscle biopsies were obtained from lean, control and obese, T2D subjects under basal and after a 2-h...

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Pubblicato in:Am J Physiol Regul Integr Comp Physiol
Autori principali: Williamson, David L., Dungan, Cory M., Mahmoud, Abeer M., Mey, Jacob T., Blackburn, Brian K., Haus, Jacob M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
Soggetti:
Obesity, Diabetes and Energy Homeostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666944/
https://ncbi.nlm.nih.gov/pubmed/26269521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00285.2015
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