Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor

BACKGROUND: The gut mucosal homing integrin receptor α4β7 present on activated CD4(+) T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressin...

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Publicado no:PLoS One
Main Authors: Peachman, Kristina K., Karasavvas, Nicos, Chenine, Agnes-Laurence, McLinden, Robert, Rerks-Ngarm, Supachai, Jaranit, Kaewkungwal, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Tovanabutra, Sodsai, Zolla-Pazner, Susan, Michael, Nelson L., Kim, Jerome H., Alving, Carl R., Rao, Mangala
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666614/
https://ncbi.nlm.nih.gov/pubmed/26625359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143895
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