Vaccine-Induced HIV-1 Envelope gp120 Constant Region 1-Specific Antibodies Expose a CD4-Inducible Epitope and Block the Interaction of HIV-1 gp140 with Galactosylceramide

Mucosal epithelial cell surface galactosylceramide (Galcer) has been postulated to be a receptor for HIV-1 envelope (Env) interactions with mucosal epithelial cells. Disruption of the HIV-1 Env interaction with such alternate receptors could be one strategy to prevent HIV-1 entry through the mucosal...

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Main Authors: Dennison, S. Moses, Anasti, Kara M., Jaeger, Frederick H., Stewart, Shelley M., Pollara, Justin, Liu, Pinghuang, Kunz, Erika L., Zhang, Ruijun, Vandergrift, Nathan, Permar, Sallie, Ferrari, Guido, Tomaras, Georgia D., Bonsignori, Mattia, Michael, Nelson L., Kim, Jerome H., Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Rerks-Ngarm, Supachai, Liao, Hua-Xin, Haynes, Barton F., Alam, S. Munir
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136246/
https://ncbi.nlm.nih.gov/pubmed/24920809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01031-14
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