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Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake
We have found that ERBB4 activates sterol regulatory element binding protein-2 (SREBP-2) to enhance expression of genes essential for cholesterol metabolism including mevalonate pathway enzymes and the low-density lipoprotein receptor (LDLR). ERBB4 is unusual among receptor kinases in undergoing lig...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4666504/ https://ncbi.nlm.nih.gov/pubmed/26535009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aac5124 |
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