Crystallographic insights into the structure–activity relationships of diazaborine enoyl-ACP reductase inhibitors

Enoyl-ACP reductase, the last enzyme of the fatty-acid biosynthetic pathway, is the molecular target for several successful antibiotics such as the tuberculosis therapeutic isoniazid. It is currently under investigation as a narrow-spectrum antibiotic target for the treatment of several types of bac...

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Vydáno v:Acta Crystallogr F Struct Biol Commun
Hlavní autoři: Jordan, Cheryl A., Sandoval, Braddock A., Serobyan, Mkrtich V., Gilling, Damian H., Groziak, Michael P., Xu, H. Howard, Vey, Jessica L.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2015
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666481/
https://ncbi.nlm.nih.gov/pubmed/26625295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15022098
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