Hemoglobin interaction with GP1bα induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis

Intravascular hemolysis increases the risk of hypercoagulation and thrombosis in hemolytic disorders. Our study shows a novel mechanism by which extracellular hemoglobin directly affects platelet activation. The binding of Hb to glycoprotein1bα activates platelets. Lower concentrations of Hb (0.37–3...

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Udgivet i:Haematologica
Main Authors: Singhal, Rashi, Annarapu, Gowtham K., Pandey, Ankita, Chawla, Sheetal, Ojha, Amrita, Gupta, Avinash, Cruz, Miguel A., Seth, Tulika, Guchhait, Prasenjit
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666328/
https://ncbi.nlm.nih.gov/pubmed/26341739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.132183
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