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Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1

Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during granulopoiesis, impairing the ability of developing...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Evans, Ceri, Orf, Katharine, Horvath, Erzsebet, Levin, Michael, De La Fuente, Josu, Chakravorty, Subarna, Cunnington, Aubrey J.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666326/
https://ncbi.nlm.nih.gov/pubmed/26315932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.128777
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