Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation

BACKGROUND: Precise spatiotemporal control of gene expression is essential for the establishment of correct cell numbers and identities during brain development. This process involves epigenetic control mechanisms, such as those mediated by the polycomb group protein Ezh2, which catalyzes trimethyla...

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Dades bibliogràfiques
Publicat a:BMC Biol
Autors principals: Zemke, Martina, Draganova, Kalina, Klug, Annika, Schöler, Anne, Zurkirchen, Luis, Gay, Max Hans-Peter, Cheng, Phil, Koseki, Haruhiko, Valenta, Tomas, Schübeler, Dirk, Basler, Konrad, Sommer, Lukas
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665911/
https://ncbi.nlm.nih.gov/pubmed/26621269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-015-0210-9
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