Platelet-derived HMGB1 is a critical mediator of thrombosis

Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular pattern molecule high-mobility group box 1 (HMGB1) is upregulated by activated platelets in multiple inf...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Vogel, Sebastian, Bodenstein, Rebecca, Chen, Qiwei, Feil, Susanne, Feil, Robert, Rheinlaender, Johannes, Schäffer, Tilman E., Bohn, Erwin, Frick, Julia-Stefanie, Borst, Oliver, Münzer, Patrick, Walker, Britta, Markel, Justin, Csanyi, Gabor, Pagano, Patrick J., Loughran, Patricia, Jessup, Morgan E., Watkins, Simon C., Bullock, Grant C., Sperry, Jason L., Zuckerbraun, Brian S., Billiar, Timothy R., Lotze, Michael T., Gawaz, Meinrad, Neal, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665785/
https://ncbi.nlm.nih.gov/pubmed/26551681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81660
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