Modulation of Innate Immune Responses via Covalently Linked TLR Agonists

[Image: see text] We present the synthesis of novel adjuvants for vaccine development using multivalent scaffolds and bioconjugation chemistry to spatially manipulate Toll-like receptor (TLR) agonists. TLRs are primary receptors for activation of the innate immune system during vaccination. Vaccines...

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Pubblicato in:ACS Cent Sci
Autori principali: Tom, Janine K., Dotsey, Emmanuel Y., Wong, Hollie Y., Stutts, Lalisa, Moore, Troy, Davies, D. Huw, Felgner, Philip L., Esser-Kahn, Aaron P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665084/
https://ncbi.nlm.nih.gov/pubmed/26640818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00274
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