The chromatin environment shapes DNA replication origin organization and defines origin classes

To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high-resolution in mouse ES cells. This allowed initiation sites (IS) and initiation zones (IZ) to be differentiated. We then characterized their genetic signatures and organizatio...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Cayrou, Christelle, Ballester, Benoit, Peiffer, Isabelle, Fenouil, Romain, Coulombe, Philippe, Andrau, Jean-Christophe, van Helden, Jacques, Méchali, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665008/
https://ncbi.nlm.nih.gov/pubmed/26560631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.192799.115
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