Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos

The CRISPR-Cas RNA-guided system has versatile uses in many organisms and allows modification of multiple target sites simultaneously. Generating novel genetically modified mouse and rat models is one valuable application of this system. Through the injection of Cas9 protein instead of mRNA into emb...

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Publicado no:Sci Rep
Main Authors: Wang, Liren, Shao, Yanjiao, Guan, Yuting, Li, Liang, Wu, Lijuan, Chen, Fangrui, Liu, Meizhen, Chen, Huaqing, Ma, Yanlin, Ma, Xueyun, Liu, Mingyao, Li, Dali
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664917/
https://ncbi.nlm.nih.gov/pubmed/26620761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17517
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