Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos

The CRISPR-Cas RNA-guided system has versatile uses in many organisms and allows modification of multiple target sites simultaneously. Generating novel genetically modified mouse and rat models is one valuable application of this system. Through the injection of Cas9 protein instead of mRNA into emb...

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Udgivet i:Sci Rep
Main Authors: Wang, Liren, Shao, Yanjiao, Guan, Yuting, Li, Liang, Wu, Lijuan, Chen, Fangrui, Liu, Meizhen, Chen, Huaqing, Ma, Yanlin, Ma, Xueyun, Liu, Mingyao, Li, Dali
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664917/
https://ncbi.nlm.nih.gov/pubmed/26620761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17517
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