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Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle

Allosteric effects of mutations, ligand binding, or post-translational modifications on protein function occur through changes to the protein’s shape, or conformation. In a cell, there are many copies of the same protein, all experiencing these perturbations in a dynamic fashion and fluctuating thro...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Biol
Main Authors: Nussinov, Ruth, Tsai, Chung-Jung
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664463/
https://ncbi.nlm.nih.gov/pubmed/26618518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002306
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