Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules

Microtubules (MTs) are hollow cytoskeletal filaments assembled from αβ-tubulin heterodimers. Tau, an unstructured protein found in neuronal axons, binds to MTs and regulates their dynamics. Aberrant Tau behavior is associated with neurodegenerative dementias, including Alzheimer’s. Here, we report o...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Chung, Peter J., Choi, Myung Chul, Miller, Herbert P., Feinstein, H. Eric, Raviv, Uri, Li, Youli, Wilson, Leslie, Feinstein, Stuart C., Safinya, Cyrus R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664379/
https://ncbi.nlm.nih.gov/pubmed/26542680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513172112
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