A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation

Regulated shedding of the ectodomain of cell membrane proteins by proteases is a common process that releases the extracellular domain from the cell and activates cell signaling. Ectodomain shedding occurs in the immediate extracellular juxtamembrane region, which is also where O-glycosylation is of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Goth, Christoffer K., Halim, Adnan, Khetarpal, Sumeet A., Rader, Daniel J., Clausen, Henrik, Schjoldager, Katrine T.-B. G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664366/
https://ncbi.nlm.nih.gov/pubmed/26554003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511175112
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