Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis

The dimeric nature of triosephosphate isomerases (TIMs) is maintained by an extensive surface area interface of more than 1600 Å(2). TIMs from Trichomonas vaginalis (TvTIM) are held in their dimeric state by two mechanisms: a ball and socket interaction of residue 45 of one subunit that fits into th...

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Publicat a:PLoS One
Autors principals: Lara-Gonzalez, Samuel, Estrella, Priscilla, Portillo, Carmen, Cruces, María E., Jimenez-Sandoval, Pedro, Fattori, Juliana, Migliorini-Figueira, Ana C., Lopez-Hidalgo, Marisol, Diaz-Quezada, Corina, Lopez-Castillo, Margarita, Trasviña-Arenas, Carlos H., Sanchez-Sandoval, Eugenia, Gómez-Puyou, Armando, Ortega-Lopez, Jaime, Arroyo, Rossana, Benítez-Cardoza, Claudia G., Brieba, Luis G.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664265/
https://ncbi.nlm.nih.gov/pubmed/26618356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141747
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