Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex

A central event in Alzheimer’s disease is the accumulation of amyloid β (Aβ) peptides generated by the proteolytic cleavage of the amyloid precursor protein (APP). APP overexpression leads to increased Aβ generation and Alzheimer’s disease in humans and altered neuronal migration and increased long...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Crenshaw, Ezekiel, Leung, Brian P., Kwok, Chun Kit, Sharoni, Michal, Olson, Kalee, Sebastian, Neeraj P., Ansaloni, Sara, Schweitzer-Stenner, Reinhard, Akins, Michael R., Bevilacqua, Philip C., Saunders, Aleister J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664259/
https://ncbi.nlm.nih.gov/pubmed/26618502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143160
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