Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling

Suppression of the hypothalamic-pituitary-adrenal (HPA) axis has been shown to occur during cholestatic liver injury. Furthermore, we have demonstrated that in a model of cholestasis, serum bile acids gain entry into the brain via a leaky blood brain barrier and that hypothalamic bile acid content i...

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Bibliographic Details
Published in:Mol Endocrinol
Main Authors: McMillin, Matthew, Frampton, Gabriel, Quinn, Matthew, Divan, Ali, Grant, Stephanie, Patel, Nisha, Newell-Rogers, Karen, DeMorrow, Sharon
Format: Artigo
Language:Inglês
Published: Endocrine Society 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664228/
https://ncbi.nlm.nih.gov/pubmed/26431088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1087
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