Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates

Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. There is, however, a clearly recognized need for new classes of compounds with the ability to reac...

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Gepubliceerd in:Chembiochem
Hoofdauteurs: Katz, Francine S., Pecic, Stevan, Tran, Timothy H., Trakht, Ilya, Schneider, Laura, Zhu, Zhengxiang, Ton-That, Long, Luzac, Michal, Zlatanic, Viktor, Damera, Shivani, Macdonald, Joanne, Landry, Donald W., Tong, Liang, Stojanovic, Milan N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664178/
https://ncbi.nlm.nih.gov/pubmed/26350723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500348
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