Platelet P2Y(12) inhibitors reduce systemic inflammation and its prothrombotic effects in an experimental human model

OBJECTIVE: Clinical studies suggest that platelet P2Y(12) inhibitors reduce mortality from sepsis, although the underlying mechanisms have not been clearly defined in vivo. We hypothesized that P2Y(12) inhibitors may improve survival from sepsis by suppressing systemic inflammation and its prothromb...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Thomas, Mark R., Outteridge, Samuel N., Ajjan, Ramzi A., Phoenix, Fladia, Sangha, Gurpreet K., Faulkner, Rachael E., Ecob, Rosemary, Judge, Heather M., Khan, Haroon, West, Laura E., Dockrell, David H., Sabroe, Ian, Storey, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663676/
https://ncbi.nlm.nih.gov/pubmed/26515417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306528
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