Platelet P2Y(12) inhibitors reduce systemic inflammation and its prothrombotic effects in an experimental human model

OBJECTIVE: Clinical studies suggest that platelet P2Y(12) inhibitors reduce mortality from sepsis, although the underlying mechanisms have not been clearly defined in vivo. We hypothesized that P2Y(12) inhibitors may improve survival from sepsis by suppressing systemic inflammation and its prothromb...

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Dades bibliogràfiques
Publicat a:Arterioscler Thromb Vasc Biol
Autors principals: Thomas, Mark R., Outteridge, Samuel N., Ajjan, Ramzi A., Phoenix, Fladia, Sangha, Gurpreet K., Faulkner, Rachael E., Ecob, Rosemary, Judge, Heather M., Khan, Haroon, West, Laura E., Dockrell, David H., Sabroe, Ian, Storey, Robert F.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663676/
https://ncbi.nlm.nih.gov/pubmed/26515417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306528
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