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Drug target prioritization by perturbed gene expression and network information

Drugs bind to their target proteins, which interact with downstream effectors and ultimately perturb the transcriptome of a cancer cell. These perturbations reveal information about their source, i.e., drugs’ targets. Here, we investigate whether these perturbations and protein interaction networks...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Isik, Zerrin, Baldow, Christoph, Cannistraci, Carlo Vittorio, Schroeder, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663505/
https://ncbi.nlm.nih.gov/pubmed/26615774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17417
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