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A DNMT3A2-HDAC2 complex is essential for genomic imprinting and genome integrity in mouse oocytes
Maternal genomic imprints are established during oogenesis. Histone deacetylases (HDACs) 1 and 2 are required for oocyte development in mouse, but their role in genomic imprinting is unknown. We find that Hdac1:Hdac2(−/−) double mutant growing oocytes exhibit global DNA hypomethylation and fail to e...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4662907/ https://ncbi.nlm.nih.gov/pubmed/26586441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.031 |
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