Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study

OBJECTIVE: To characterize the population pharmacokinetic (PK) of oral methadone in neonates requiring pharmacologic treatment of neonatal abstinence syndrome (NAS) and to develop a PK model towards an evidence-based treatment protocol. STUDY DESIGN: Based on a methadone dosing protocol, serum conce...

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Detalhes bibliográficos
Publicado no:J Pediatr
Main Authors: Wiles, Jason R., Isemann, Barbara, Mizuno, Tomoyuki, Tabangin, Meredith E., Ward, Laura P., Akinbi, Henry, Vinks, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662899/
https://ncbi.nlm.nih.gov/pubmed/26364984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2015.08.032
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