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The Pharmacokinetics of Methadone and its Metabolites in Neonates, Infants and Children
BACKGROUND: The lack of methadone pharmacokinetic data in children and neonates restrains dosing to achieve the target concentration in these populations. A minimum effective analgesic concentration of methadone in opioid naïve adults is 0.058 mg.L(−1), while no withdrawal symptoms were observed in...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4016164/ https://ncbi.nlm.nih.gov/pubmed/24666686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pan.12385 |
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