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Treatment of a mouse model of ankylosing spondylitis with exogenous sclerostin has no effect on disease progression
BACKGROUND: No treatment to date is available which specifically targets bone formation in ankylosing spondylitis (AS). Several recent studies have shown that sclerostin (SOST), a Wnt inhibitor specific to osteocytes and chondrocytes, is down-regulated in AS patients. This suggests Wnt signalling ma...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | BMC Musculoskelet Disord |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4662039/ https://ncbi.nlm.nih.gov/pubmed/26612313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-015-0823-8 |
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