Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients

BACKGROUND: Acute myeloid leukemia (AML) patients with highly active AKT tend to do poorly. Cell cycle arrest and apoptosis are tightly regulated by AKT via phosphorylation of GSK3α and β isoforms which inactivates these kinases. In the current study we examine the prognostic role of AKT mediated GS...

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Dettagli Bibliografici
Pubblicato in:BBA Clin
Autori principali: Ruvolo, Peter P., Qiu, YiHua, Coombes, Kevin R., Zhang, Nianxiang, Neeley, E. Shannon, Ruvolo, Vivian R., Hail, Numsen, Borthakur, Gautam, Konopleva, Marina, Andreeff, Michael, Kornblau, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
Soggetti:
Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661707/
https://ncbi.nlm.nih.gov/pubmed/26674329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbacli.2015.07.001
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