Pharmacokinetics and Dosimetry Studies for Optimization of Pretargeted Radioimmunotherapy in CEA-Expressing Advanced Lung Cancer Patients

OBJECTIVES: A phase I pretargeted radioimmunotherapy trial (EudractCT 200800603096) was designed in patients with metastatic lung cancer expressing carcinoembryonic antigen (CEA) to optimize bispecific antibody and labeled peptide doses, as well as the delay between their injections. METHODS: Three...

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Опубликовано в: :Front Med (Lausanne)
Главные авторы: Bodet-Milin, Caroline, Ferrer, Ludovic, Rauscher, Aurore, Masson, Damien, Rbah-Vidal, Latifa, Faivre-Chauvet, Alain, Cerato, Evelyne, Rousseau, Caroline, Hureaux, José, Couturier, Olivier, Salaün, Pierre-Yves, Goldenberg, David M., Sharkey, Robert M., Kraeber-Bodéré, Françoise, Barbet, Jacques
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2015
Предметы:
Medicine
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661432/
https://ncbi.nlm.nih.gov/pubmed/26640780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2015.00084
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