Pharmacokinetics and Dosimetry Studies for Optimization of Pretargeted Radioimmunotherapy in CEA-Expressing Advanced Lung Cancer Patients

OBJECTIVES: A phase I pretargeted radioimmunotherapy trial (EudractCT 200800603096) was designed in patients with metastatic lung cancer expressing carcinoembryonic antigen (CEA) to optimize bispecific antibody and labeled peptide doses, as well as the delay between their injections. METHODS: Three...

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Dettagli Bibliografici
Pubblicato in:Front Med (Lausanne)
Autori principali: Bodet-Milin, Caroline, Ferrer, Ludovic, Rauscher, Aurore, Masson, Damien, Rbah-Vidal, Latifa, Faivre-Chauvet, Alain, Cerato, Evelyne, Rousseau, Caroline, Hureaux, José, Couturier, Olivier, Salaün, Pierre-Yves, Goldenberg, David M., Sharkey, Robert M., Kraeber-Bodéré, Françoise, Barbet, Jacques
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
Soggetti:
Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661432/
https://ncbi.nlm.nih.gov/pubmed/26640780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2015.00084
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