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An Unprecedented Combination of Serine and Cysteine Nucleophiles in a Split Intein with an Atypical Split Site

Protein splicing mediated by inteins is a self-processive reaction leading to the excision of the internal intein domain from a precursor protein and the concomitant ligation of the flanking sequences, the extein-N and extein-C parts, thereby reconstituting the host protein. Most inteins employ a sp...

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Pubblicato in:J Biol Chem
Autori principali: Bachmann, Anne-Lena, Mootz, Henning D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661395/
https://ncbi.nlm.nih.gov/pubmed/26453311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677237
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