The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer

The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its function remains poorly understood. Here, we report that BAP1 forms two mutually exclusive complexes with the transcriptional...

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Vydáno v:J Biol Chem
Hlavní autoři: Daou, Salima, Hammond-Martel, Ian, Mashtalir, Nazar, Barbour, Haithem, Gagnon, Jessica, Iannantuono, Nicholas V. G., Nkwe, Nadine Sen, Motorina, Alena, Pak, Helen, Yu, Helen, Wurtele, Hugo, Milot, Eric, Mallette, Frédérick A., Carbone, Michele, Affar, El Bachir
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661380/
https://ncbi.nlm.nih.gov/pubmed/26416890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661553
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