POD-1/Tcf21 overexpression reduces endogenous SF-1 and StAR expression in rat adrenal cells

During gonad and adrenal development, the POD-1/capsulin/TCF21transcription factor negatively regulates SF-1/NR5A1expression, with higher SF-1 levels being associated with increased adrenal cell proliferation and tumorigenesis. In adrenocortical tumor cells, POD-1 binds to the SF-1 E-box promoter re...

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Bibliographic Details
Published in:Braz J Med Biol Res
Main Authors: França, M. M., Abreu, N. P., Vrechi, T. A. M., Lotfi, C. F.
Format: Artigo
Language:Inglês
Published: Associação Brasileira de Divulgação Científica 2015
Subjects:
Biomedical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661024/
https://ncbi.nlm.nih.gov/pubmed/26421867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1414-431X20154748
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