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Lewis acid-promoted hydrofluorination of alkynyl sulfides to generate α-fluorovinyl thioethers

A new method for the preparation of α-fluorovinyl thioethers is reported which involves the hydrofluorination of alkynyl sulfides with 3HF·Et(3)N, a process that requires Lewis acid activation using BF(3)·Et(2)O and TiF(4). The method gives access to a range of α-fluorovinyl thioethers, some in high...

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Detalhes bibliográficos
Publicado no:Beilstein J Org Chem
Main Authors: Bello, Davide, O'Hagan, David
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661019/
https://ncbi.nlm.nih.gov/pubmed/26664609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.11.205
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