Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

Cytochrome P450 monooxygenases are useful biocatalysts for C–H activation, and there is a need to expand the range of these enzymes beyond what is naturally available. A panel of 93 variants of active self-sufficient P450cam[Tyr96Phe]-RhFRed fusion enzymes with a broad diversity in active site amino...

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Foilsithe in:Beilstein J Org Chem
Main Authors: Kelly, Paul P, Eichler, Anja, Herter, Susanne, Kranz, David C, Turner, Nicholas J, Flitsch, Sabine L
Formáid: Artigo
Teanga:Inglês
Foilsithe: Beilstein-Institut 2015
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Full Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660908/
https://ncbi.nlm.nih.gov/pubmed/26664590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.11.186
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