Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis

BACKGROUND: Tamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using the inducible Cre-Lox technique. Despite its widespread use in the clinic and laboratory, we know little about its effects on the nervous system. This is of significant c...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Denk, Franziska, Ramer, Leanne M., Erskine, Erin L. K. S., Nassar, Mohammed A., Bogdanov, Yury, Signore, Massimo, Wood, John N., McMahon, Stephen B., Ramer, Matt S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660723/
https://ncbi.nlm.nih.gov/pubmed/26610346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0255-6
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