Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells

This work aims to provide sampling of halogen-containing aniline podophyllum derivatives and their mode of action with an in-depth comparison among fluorine, chloride and bromide for clarifying the important role and impact of fluorine substitution on enhancing antitumor activity, with an emphasis o...

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Publicado no:Sci Rep
Main Authors: Zhao, Wei, Yang, Yong, Zhang, Ya-Xuan, Zhou, Chen, Li, Hong-Mei, Tang, Ya-Ling, Liang, Xin-Hua, Chen, Tao, Tang, Ya-Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660440/
https://ncbi.nlm.nih.gov/pubmed/26608216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17175
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