Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes

RAG initiates antibody V(D)J recombination in developing lymphocytes by generating “on-target” DNA breaks at matched pairs of bona fide recombination signal sequences (RSSs). We employ bait RAG-generated breaks in endogenous or ectopically-inserted RSS pairs to identify huge numbers of RAG “off-targ...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Hu, Jiazhi, Zhang, Yu, Zhao, Lijuan, Frock, Richard L., Du, Zhou, Meyers, Robin M., Meng, Fei-long, Schatz, David G., Alt, Frederick W.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660266/
https://ncbi.nlm.nih.gov/pubmed/26593423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.10.016
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