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Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes
RAG initiates antibody V(D)J recombination in developing lymphocytes by generating “on-target” DNA breaks at matched pairs of bona fide recombination signal sequences (RSSs). We employ bait RAG-generated breaks in endogenous or ectopically-inserted RSS pairs to identify huge numbers of RAG “off-targ...
Tallennettuna:
Julkaisussa: | Cell |
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Päätekijät: | , , , , , , , , |
Aineistotyyppi: | Artigo |
Kieli: | Inglês |
Julkaistu: |
2015
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Aiheet: | |
Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4660266/ https://ncbi.nlm.nih.gov/pubmed/26593423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.10.016 |
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