Amelioration of Hyperglycemia with a Sodium-Glucose Cotransporter 2 Inhibitor Prevents Macrophage-Driven Atherosclerosis through Macrophage Foam Cell Formation Suppression in Type 1 and Type 2 Diabetic Mice

Direct associations between hyperglycemia and atherosclerosis remain unclear. We investigated the association between the amelioration of glycemia by sodium-glucose cotransporter 2 inhibitors (SGLT2is) and macrophage-driven atherosclerosis in diabetic mice. We administered dapagliflozin or ipraglifl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Terasaki, Michishige, Hiromura, Munenori, Mori, Yusaku, Kohashi, Kyoko, Nagashima, Masaharu, Kushima, Hideki, Watanabe, Takuya, Hirano, Tsutomu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659635/
https://ncbi.nlm.nih.gov/pubmed/26606676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143396
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