Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress

We screened a panel of mouse and human monoclonal antibodies (MAbs) against chikungunya virus and identified several with inhibitory activity against multiple alphaviruses. Passive transfer of broadly neutralizing MAbs protected mice against infection by chikungunya, Mayaro, and O’nyong’nyong alphav...

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Bibliografski detalji
Izdano u:Cell
Glavni autori: Fox, Julie M., Long, Feng, Edeling, Melissa A., Lin, Hueylie, van Duijl-Richter, Mareike K.S., Fong, Rachel H., Kahle, Kristen M., Smit, Jolanda M., Jin, Jing, Simmons, Graham, Doranz, Benjamin J., Crowe, James E., Fremont, Daved H., Rossmann, Michael G., Diamond, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659373/
https://ncbi.nlm.nih.gov/pubmed/26553503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.10.050
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