Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress

We screened a panel of mouse and human monoclonal antibodies (MAbs) against chikungunya virus and identified several with inhibitory activity against multiple alphaviruses. Passive transfer of broadly neutralizing MAbs protected mice against infection by chikungunya, Mayaro, and O’nyong’nyong alphav...

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Published in:Cell
Main Authors: Fox, Julie M., Long, Feng, Edeling, Melissa A., Lin, Hueylie, van Duijl-Richter, Mareike K.S., Fong, Rachel H., Kahle, Kristen M., Smit, Jolanda M., Jin, Jing, Simmons, Graham, Doranz, Benjamin J., Crowe, James E., Fremont, Daved H., Rossmann, Michael G., Diamond, Michael S.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659373/
https://ncbi.nlm.nih.gov/pubmed/26553503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.10.050
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