Establishment of an artificial β-cell line expressing insulin under the control of doxycycline

AIM: Artificial β-cell lines may offer an abundant source of cells for the treatment of type I diabetes, but insulin secretion in β-cells is tightly regulated in physiological conditions. The Tet-On system is a “gene switch” system, which can induce gene expression by administration of tetracycline...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Qin, Xin-Yu, Shen, Kun-Tang, Zhang, Xin, Cheng, Zhi-Hong, Xu, Xiang-Ru, Han, Ze-Guang
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2002
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658386/
https://ncbi.nlm.nih.gov/pubmed/11925627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v8.i2.367
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