Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation

IL-7 is known to be vital for T cell homeostasis but has previously been presumed to be dispensable for TCR-induced activation. Here, we show that IL-7 is critical for the initial activation of CD4(+) T cells in that it provides some of the necessary early signaling components, such as activated STA...

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Udgivet i:Clin Immunol
Main Authors: Lawson, Brian R., Gonzalez-Quintial, Rosana, Eleftheriadis, Theodoros, Farrar, Michael A., Miller, Stephen D., Sauer, Karsten, McGavern, Dorian B., Kono, Dwight H., Baccala, Roberto, Theofilopoulos, Argyrios N.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658267/
https://ncbi.nlm.nih.gov/pubmed/26319414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.08.007
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