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Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade
Lupus is characterized by disturbances in lymphocyte homeostasis, as demonstrated by the marked accumulation of activated/memory T cells. Here, we provide evidence that proliferation of the CD8(+) precursors for the accumulating CD4(–)CD8(–) T cells in MRL-Fas(lpr) lupus-predisposed mice is, in part...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3213145/ https://ncbi.nlm.nih.gov/pubmed/22102903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027528 |
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